Dr Sjoerd Rijpkema
Dr Sjoerd Rijpkema has an interest in the interaction between pathogenic bacteria and the human and animal host, in particular the mechanisms that lie behind colonisation, invasion and pathogenicity.
He investigated the protective mechanism of live and killed oral cholera vaccines at the Dutch National Institute of Public Health and the Environment (RIVM). As part of his PhD project, he developed assays for diagnosing Lyme borreliosis in patients and for DNA typing of Borrelia species in ticks and patients. He received his PhD from the Faculty of Veterinary Science, University of Utrecht (Netherlands) in 1995.
In 1997 he moved to NIBSC, where he is responsible for the release of anthrax, typhoid and cholera vaccines for the UK and European markets. He has developed an infection model to study Helicobacter pylori infections and assays to analyse vaccine components and to study the role of bacterial toxins such as anthrax lethal toxin and cholera toxin at cellular level. Recently, he has become involved in standardisation programmes for Vi serology and the development of immunoassays to aid the standardisation and licencing of Vi conjugate vaccines for typhoid. He is also involved in the development and characterisation of diagnostic standards for toxoplasma, syphilis and Chagas disease.
He has published more than 60 scientific papers, produced 4 reports on the validation of the World Health Organisation’s (WHO) International Standards, European Pharmacopeia monographs for anthrax and oral cholera vaccines, and has written a section of the WHO guidelines for typhoid conjugate vaccines.