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The National Institute for Biological Standards and Control

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  • Dr Sanj Raut

Dr Sanj Raut

Dr Raut is a Pharmacologist by training with his undergraduate and PhD degrees from the University of Liverpool.

He joined NIBSC in 1993 and has over 25-years’ experience in the field of Haemostasis and Haemophilia, gained principally at NIBSC.

He is responsible for the development and upkeep of World Health Organization WHO International Standards, British Standards and European Standards for Coagulation Factor VIII (FVIII), with a focus on standardisation of both recombinant and plasma derived FVIII concentrates.  Other standardisation responsibilities include assays of fibrinogen, factor XIII, FVIII bypassing agents and neutralising antibodies (inhibitors) to FVIII.

His laboratory performs Independent Control Testing of FVIII therapeutic concentrates (for both UK and non-UK batch release)

His research interests include the measurement, mechanisms of action and immunogenicity of current and novel FVIII therapeutics, as well as haemophilia gene and cell therapy.

He has over 50 peer-reviewed publications covering various aspects of Haemostasis and Haemophilia.

 
Current position

Principal Scientist, Haemostasis Section, Division of Biotherapeutics

Areas of interest

Blood coagulation Factor VIII (FVIII), both recombinant and plasma-derived
Development of sensitive biological assays for detection of low levels of FVIII and their antibodies (inhibitors)
Haemophilia gene and cell therapy
Immunogenicity of FVIII
Recombinant antibodies to FVIII
Structural and allosteric modification of recombinant FVIII

Qualifications

1992: PhD Endocrinology, University of Liverpool
1988: BSc Zoology, University of Liverpool
1987: BSc Pharmacology, University of Liverpool

Publications

For full list of publications see Researcher ID

Representation on external committees

Co-chair of Factor XIII/Fibrinogen subcommittee of the International Society for Thr  ombosis and Haemostasis (ISTH) Scientific and Standardisation Committee (SSC)

Co-chair/member of Standing Advisory Committee for Blood Components (SAC-BC) of the Joint United Kingdom Blood Transfusion and Tissue Transplantation Services (UKBTS) Professional Advisory Committee (JPAC)
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