NIBSC - Dr Paul Matejtschuk

Dr Paul Matejtschuk

Dr Paul Matejtschuk leads a team in the development of formulation and freeze drying processes for the International Standards and other reference materials produced by NIBSC.

He has broad experience across downstream processing including lyophilisation, analytical and preparative chromatography, ultrafiltration, glycan analysis, peptide mapping and protein chemistry.

His most recent experience has been in the biological application of thermal analysis, formulation and lyophilisation of biologicals, high throughput screening methods, application of Design of Experiments (DoE) and Process Analytical Technology (PAT) in freeze drying as well as the measurement of residual water and its impact on the stability of biologics

Current position

Principal Scientist and Section Head, Standardisation Science Technology, Development & Infrastructure Division

Areas of interest

Freeze drying
Biologics formulation
Thermal analysis
Protein chemistry
Biologics characterisation
Quality by Design
High Throughput Analysis methods

Qualifications

2011: CChem, Royal Society of Chemistry, London, UK
1986: PhD, Chemistry, University of Warwick
1982: BSc, Biochemistry, University of York

Recent publications (PDF, 122KB)

Representation on external committees

Royal Society of Chemistry Thermal Methods Group
International Society for Lyophilisation Freeze Drying
Represents NIBSC as their User Group member at the EPSRC Future Targeted Healthcare Manufacturing Hub
BIPM Committee for the Amount of Substance
NIBSC representative at the UK National Measurement Forum
NIBSC representative on the British Standards Institution (BSI) Reference Materials Committee

External grants and contracts secured over the past 10 years

PhD studentships
PhD studentship (EPSRC ) with Dr Paul Dalby, University College London (2006-2010)
PhD studentship (BBSRC BRIC) with Prof Paul Dalby, University College London (2011-2015)
PhD studentship (EPSRC Centre for Doctoral Training) with Prof Paul Dalby, University College London (2014-2018) (2018-ongoing)
PhD studentship (EPSRC Centre for Doctoral Training) with Dr Daryl Williams Reader in Particle Science, Imperial College London (2015-2019)

Innovate UK Grants
BioStaRT (2014-18) and AtlasBio (2017-2020) for Collaborative R&D in freeze drying technology with Prof Geoff Smith Leceister School of Pharmacy, De Montfort University