Dr Donna Bryan joined the NIBSC in 1998. Her research interests are varied having worked on several projects over the years, both in academia and at the NIBSC. Currently, Donna works in the Enterics Group where she manages the research and standardisation projects for the development of reference materials for health care associated infection caused by Clostridioides difficile. Her PhD was obtained in 1998 from Barts and the London school of Medicine and Dentistry, Queen Mary University of London.
Publications
S. Anwar, D. Bryan, P. Rigsby, T. Dougall, S. Rijpkema 2020. Development and verification of an Enzyme-linked immunosorbent assay for the quantification of toxoid A and toxoid B from Clostridioides difficile Journal of Immunological Methods (Submitted)
Hannah Cole, Donna Bryan, Lorna Lancaster, Fatme Mawas, Driton Vllasaliu 2018. Chitosan nanoparticle antigen uptake in epithelial monolayers does not predict in vivo immune response by oral delivery. Carbohydrate Polymers190:248-254
Steven G. Smith, Stephanie A. Harris, Iman Satti, Donna Bryan, K. Barry Walker, Hazel M.Dockrell, Helen McShane, Mei Mei Ho 2017. Assay optimisation and technology transfer for multi-site immuno-monitoring in vaccine trials. PLoS ONE 12(10): e0184391.
Bryan, D., Silva, N., Rigsby, P., Dougall, T., Corran, P., Bowyer, P. W., Ho, M. M. & Collaborative Study Group 2017. The establishment of a WHO Reference Reagent for anti-malaria (Plasmodium falciparum) human serum. Malaria Journal, 16, 314.
Hong, Huynh A.; Hitri, Krisztina; Hosseini, Siamand; Kotowicz, Natalia; Bryan, Donna; Mawas, Fatme; Wilkinson, Anthony J.; van Broekhoven, Annie; Kearsey, Jonathan; Cutting, Simon M. 2017. Mucosal antibodies to the C terminus of toxin A prevent colonization of Clostridium difficile. Infection and Immunity, Vol. 85, No. 4, e01060-16, 01.04.
Bibi, S, Bryan, D, Lattman, E, Walker, B, Perrie, Y (2012). Trigger release liposomes for use as reference standards in the ELISPOT assay. 12th European Symposium on Controlled Drug Delivery, Egmond En Zee, Netherlands.
Bibi, S, Bryan, D, Lattman, E, Walker, B, Perrie, Y (2011). Sedimentation characteristics of liposome formulations for use as reference standards in the ELISPOT assay. 38th Annual Meeting & Exposition of the Controlled Release Society, Maryland, USA Abstract #100184.
Bibi, S, Bryan, D, Lattman, E, Walker, B, Perrie, Y (2011). Sedimentation characteristics of liposome formulations for use as reference standards in the ELISPOT Assay. 17th UKICRS Symposium, Queens University, Belfast, UK
Van Ree R, Chapman MD, Ferreira F, Vieths S, Bryan D, et al. 2008. The CREATE project: Develoment of certified reference material for allergenic products and validation of methods for their quantification. Allergy 63(3) :310-26
Chapman MD, Ferreira F, Villalba M, Cromwell O, Bryan D et al. 2008. The European Union CREATE project: a model for International standardisation of allergy diagnostics and vaccines. J. Allergy Clin. Immunol. 122(5): 882-889.
Meager A, Visvalingam K, Dikger P, Bryan D, Wadhwa M. .2005. Biological activity of Interleukins-28 and 29: comparison with type 1 Interferons. Cytokine 31(2):109-18.
Bryan D, Walker KB, Ferguson M, and Thorpe R. 2005. Cytokine gene expression in a murine wound healing model. Cytokine 31(6):429-38.
Bryan, D., C. J. Sexton, C. Proby, A. Dalley, I. McKay, I. Leigh. 1991. Effect of immortalisation by HPV on secretion of IL-6 by oral keratinocytes Br. J. Dermatol 125: 489.
Bryan, D., C. J. Sexton, A. Dalley, G. Howells, I. Leigh, I. McKay. 1992. Analysis of the effect of E6 and E7 proteins of human papillomavirus types 11 and 16 on IL-6 secretion of human keratinocytes. Br. J. Dermatol 127(4): 428.
Bryan, D, S. Aylwin, D. Newman, J. Burrin. 1996. Characterisation of steroidogenic factor-1 binding to gonadotrophin alpha subunit DNA using surface plasmon resonance J. Endocrinol 151(suppl) P69.
Bryan, D, S. Aylwin, J. Burrin. 1997. Kinectic analysis of steroidogenic factor-1 binding to the gonadotroph specific DNA element J. Endocrinol 155(Suppl 2) P49
Kumar, V., R. Barnard, A. Dalley, D. Bryan, K. Brown, I. McKay, N. Williams, I. Leigh. 1992. Cross talk between epidermal growth factor (EGF) and IL-6 dependent pathways for regulation of keratinocyte proliferation. Br. J. Dermatol 127(4) 429
Bryan, D., C. J. Sexton, C. Proby, A. Dalley, I. Mckay, I. Leigh. 1995. Human keratinocytes harbouring human papillomavirus type 16 genomes show elevated secretion of IL-6. Cell Growth and Differentiation 6:1245-1250
Bryan, D, S. Aylwin, J. Burrin. 1999. Steroidogenic factor-1 DNA binding: A kinetic analysis using surface Plasmon resonance. J. Mol Endocrnol 22(3):241-9