Dr Carl Dolman
With an academic background focussed on the production, purification and characterisation of monoclonal antibodies, Carl Dolman began working with NIBSC in 1996 and has since become the Study Director of the Therapeutic Immunoglobulins and Allergens area. This is now part of the larger Parenterals Section within the Biotherapeutics Group.
His team is responsible for the control testing of over 200 batches of therapeutic immunoglobulin per year, as well as a number of monoclonal antibody and allergen products. It also performs centrally authorised products (CAP) and drug investigation testing on behalf of the MHRA and European Directorate for the European Directorate for the Quality of Medicines and Healthcare (EDQM). His group has also participated in many EDQM run biological standardisation programs (BSP: 039, 044, 068, 071, 099, 108) such as the establishment of Human Immunoglobulin BRP Batches 4 & 5 (BSP099). It was also a participant in the recent rhPTH1-34 standardisation project.
Carl has been an active participant at annual OMCL meetings since 1999 and became an elected member of the Advisory Group to the General OMCL network (AdG-GEON) in 2011 for four years. He is the NIBSC local administrator of the EDQM central European batch release database and is also responsible for extraction of the data for the NIBSC annual OMCL reports for both blood products and vaccines.
Present research interests include; HPLC analysis of biosimilars, purification of virus particles, affinity purification and analysis of HIV envelope proteins; study of aggregate and dimer levels in therapeutic immunoglobulins, purification of monoclonal antibodies for use as international standards.
A major role for Carl during 2014-15 is the role out of a new batch release database “CT-LIMS” that will handle sample information from receipt at NIBSC through to testing, results entry and authorization. The system will also enable automatic dispatch of a batch release certificate to the manufacturer and upload of batch certificate details to the EDQM central European database.