Dr Bhagwati Khatri is a senior scientist leading Tuberculosis (TB) research at NIBSC. Bhagwati’s research interest lies in understanding the immune response in protection against Mycobacteria tuberculosis, the causative agent of TB. In collaboration with many research and academic institutes, she is evaluating BCG efficacy in a co-infection (TB and malaria) and TB meningitis mouse model for deciphering comprehensive immune response parameters. Multi-Drug Resistant TB is one of the major challenges and she is interested in establishing proof-of-concept in using engineered macrophages as an immunotherapy for TB.
The NIBSC TB research group has an established TB aerosol mouse model and Bhagwati is open for collaborations across the TB field.
Bhagwati has extensive knowledge and experience in the field of TB and prior to moving to NIBSC, she was working in the field of vaccine development against Bovine TB in cattle at Animal and Plant Health Agency (APHA), UK. Her PhD was in Organic Chemistry from India and started working at the APHA, UK in the diagnostic and research divisions.
Efficacy and immunogenicity of different BCG doses in BALB/c and CB6F1 mice when challenged with H37Rv or Beijing HN878. Bhagwati Khatri, James Keeble, Belinda Dagg, Daryan A Kaveh, Phillip J Hogarth, Mei Mei Ho.
Higher mass meningococcal group C-tetanus toxoid vaccines conjugated with carbodiimide correlate with greater immunogenicity. Kay Lockyer, Fang Gao, Robert J Francis, David Eastwood, Bhagwati Khatri, Richard Stebbings, Jeremy P Derrick, Barbara Bolgiano. Vaccine, 2020, 38 (13), 2859-2869.
Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes. D Evangelopoulos, GA Prosser, A Rodgers, BM Dagg, B Khatri, MM Ho, Maximiliano G Gutierrez, Teresa Cortes, Luiz Pedro S de Carvalho. Nature communications, Sep 2019, 10 (1), 1-11.Comparison of pellicle and shake flask-grown BCG strains by quality control assays and protection studies. Fitzpatrick M, Ho MM, Clark S, Dagg B, Khatri B, Lanni F, Williams A, Brennan M, Laddy D, Walker B. Tuberculosis, Jan 2019, 114:47-53.Cross-laboratory evaluation of multiplex bead assays including independent common reference standards for immunological monitoring of observational and interventional human studies. Krista E. van Meijgaarden, Bhagwati Khatri, Steven G. Smith, Anne M.H.F. Drittij, Roelof A. de Paus, Jelle J. Goeman, Mei M. Ho, Hazel M. Dockrell, Helen McShane, Simone A. Joosten, Tom H.M. Ottenhoff. PloS One. 2018 Sep 4;13(9).Experimental infection of cattle with Mycobacterium tuberculosis isolates shows the attenuation of the human tubercle bacillus for cattle. Stephen Gordon, Bernardo Villarreal-Ramos, Stefan Berg, Adam Whelan, Sebastien Holbert, Florence Carreras, Franscisco Salguero, Bhagwati Khatri, Kerri Malone, Kévin Rue-Albrecht, Ronan Shaugnessy, Alicia Smyth, Gobena Ameni, Abraham Aseffa, Pierre Sarradin, Nathalie Winter, and Martin Vordermeier. Sci Rep.2018 Jan 17;8(1):894.Potential for rapid antibody detection to identify tuberculous cattle with non-reactive tuberculin skin test results.Waters WR, Vordermeier HM, Rhodes S, Khatri B, Palmer MV, Maggioli MF, Thacker TC, Nelson JT, Thomsen BV, Robbe-Austerman S, Bravo Garcia DM, Schoenbaum MA, Camacho MS, Ray JS, Esfandiari J, Lambotte P, Greenwald R, Grandison A, Sikar-Gang A, Lyashchenko KP. BMC Vet Res. 2017 Jun 7;13(1):164. doi: 10.1186/s12917-017-1085-5. A mycobacterial growth inhibition assay (MGIA) for bovine TB vaccine development.Pepponi I, Khatri B, Tanner R, Villarreal-Ramos B, Vordermeier M, McShane H. Tuberculosis (Edinb). 2017 Sep; 106:118-122. doi: 10.1016/j.tube.2017.07.008. Epub 2017 Jul 22.Tuberculin Skin Testing Boosts Interferon-gamma Responses to DIVA Reagents in M. bovis-infected Cattle. Gareth J. Jones, Mick Coad, Bhagwati Khatri, Beatriz Romero, Natalie A. Parlane, Bryce M. Buddle, Bernardo Villarreal-Ramos, H. Martin Vordermeier. Clinical Vaccine Immunology. 2017 May 5;24(5).BCG Δzmp1 Vaccine Induces Enhanced Antigen Specific Immune Responses In Cattle. Bhagwati Khatri, Adam Whelan, Derek Clifford and H. Martin Vordermeier. Vaccine, 32, 779-784, 2014.Systems-Based Approaches to Probing Metabolic Variation within the Mycobacterium tuberculosis Complex. Emma K Lofthouse, Paul R Wheeler, Dany JV Beste, Bhagwati L Khatri, Huihai Wu, Tom A Mendum, Andrzej M Kierzek and Johnjoe McFadden. PLoS One. 2013 Sep 17; 8(9): e75913.Development of an Unbiased Antigen Mining Approach to Identify Novel Vaccine Antigens and Diagnostic Reagents for Bovine Tuberculosis. Gareth J. Jones, Bhagwati Khatri, Carmenchu Garcia-Pelayo, Daryan Kaveh, Veronique Bachy, Phil Hogarth, Esen Wooff, Paul Golby, Martin Vordermeier. Clin Vaccine Immunol 2013 Nov 28; 20(11):1675-82. Epub 2013 Aug 28.High throughput phenotypic analysis of Mycobacterium tuberculosis and Mycobacterium bovis strains’ metabolism using Biolog Phenotype Microarrays. Khatri, B, Fielder, M, Jones, G, Newell, W, Abu-Oun, and Wheeler, P.R. PLoS One 2013, 8 (1).A natural-transmission model of bovine tuberculosis provides novel disease insights. Khatri BL, Coad M, Clifford DJ, Hewinson RG, Whelan AO, Vordermeier HM. Vet Rec.2012 Nov 3; 171(18):448. Lack of correlation between BCG-induced tuberculin skin test sensitization and protective immunity in cattle. Whelan AO, Coad M, Upadhyay BL(Khatri), Clifford DJ, Hewinson RG, Vordermeier HM.;Vaccine. 2011 Jul 26; 29(33):5453-8. Epub 2011 Jun 2.Development of a skin test for bovine tuberculosis for differentiating infected from vaccinated animals. Whelan AO, Clifford D, Upadhyay B(Khatri), Breadon EL, McNair J, Hewinson GR, Vordermeier MH.; J Clin Microbiol. 2010 Sep; 48(9): 3176-81. Epub 2010 Jun 30.Synthesis of amino pyridines as potential antimicrobial agent. B.L.Khatri, T. A. Upadhyay and H.H.Parekh, Oriental J. of Chemistry, 19(1), 193, 2003.
Microwave induced an expeditious synthesis of 4-thiazolidinones as antimicrobial agents. B. L. Khatri, A. M. Trivedi, V. A. Sodha, H. M. Hirpara and H. H. Parekh in Indian Journal of Heterocyclic Chemistry, Vol.12, Oct-Dec 2002, pp. 175-176.
Antimicrobial evaluation of some isoxazoles. Bhagwati L. Khatri, Tejas A. Upadhyay, Ashish M. Trivedi, Vishal Sodha and Hansa H.Parekh, J. Inst. Chemist, 74(6), 205, 2002.
Synthesis and biological screening of some novel aryl amides. Bhagwati L. Khatri, Tejas Upadhyay, Ashish Trivedi, Vishal Sodha and Hansa Parekh, J. Inst. Chemist, 75(1), 9, 2003.
N-aroylamino-2-(p-carboxyphenyl-fur-2-yl) azomethine. Sodha, Vishal; Hirpara, Hitin; Khatri, Bhagwati; Trivedi, Ashish; Parikh, A. R. Journal of the Institution of Chemists (India) (2003), 75(4), 119-120.
Microwave assisted synthesis and antimicrobial activity of some new thiazolidinones. Sodha, V. A.; Hirpara, H. M.; Trivedi, A. M.; Khatri, B. L.; Parikh, A. R. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2003), 42B (11), 2892-2895.
Synthesis and antitubercular activity of a -arylamino-a -2-(p-carboxyphenyl-fur-2-yl) acetonitriles. Sodha, Vishal; Hirpara, Hitin; Khatri, Bhagwati; Trivedi, Ashish; Parikh, A. R. Journal of the Institution of Chemists (India)
(2003), 75(2), 4-65
N-arylsulfonamido-2-[5-(p-carboxyphenyl)-2-furyl]azomethine. Sodha, Vishal; Hirpara, Hitin; Khatri, Bhagwati; Trivedi, Ashish; Parikh, A. R. Journal of the Institution of Chemists (India) (2003), 75(1), 22-23.
Microwave-assisted synthesis and biological activities of some bridgehead nitrogen heterocycles. Hirpara, H. M.; Sodha, V. A.; Trivedi, A. M.; Khatri, B. L.; Parikh, A. R. Indian Journal of Chemistry
, Section B: Organic Chemistry Including Medicinal Chemistry (2003), 42B (7), 1756-1759.