NIBSC - Product details

ID	1161
Title	LAI-M184V (3TC-resistant)
Characteristics	Produced by electroporation of MT-2 cells with HIV-1 LAI proviral DNA encoding the M184V RT substitution. Highly cytopathic; replicates to high titers (>105 TCID50/ml). The virus is highly resistant to 3TC, with IC50 values >60 µM in HeLa-CD4/LacZ-1 cell
Source	Dr. John Mellors and Dr. Raymond Schinazi.
Reference	Schinazi RF. Antimicrob Agents Chemother 37:875-881, 1993.