The traditional cold ethanol fractionation - Cohn or Kistler and Nitschmann processes - of large plasma pools still forms the basis of most albumin purification procedures, although some manufacturers have introduced additional or alternative chromatographic procedures.
Modern human albumin solutions are typically 95-98% pure and are produced at 2 concentrations – 4.5-5% albumin and 20-25% albumin.
We test and release batches of albumin solutions. Testing is performed in line with current UK Guidelines for Independent Control Testing.
Our laboratory also tests additional batches for non-UK release, and carries out PKA assays under contract.
Find out more about NIBSC control testing.
Bernard FoxGraham RobertsGiles Sharp