Red blood cell genotyping

Reference reagents for blood group genotyping

Establishing blood groups by genotyping is becoming increasingly used as it has a number of advantages over conventional blood group serology – when reliable and consistent serological reagents are unavailable to type minor antigens and variants, for blood-typing red cells with a positive direct antiglobulin test, and typing multiply transfused patients. 

Genotyping can also be used to resolve reagent typing discrepancies, and predicting foetal Rh D phenotype and some other clinically important blood groups from cell-free foetal DNA in maternal blood.

Preparations 10/232 (RBC1; AR1R1), 10/234 (RBC12; ODΨ), 10/236 (RBC4; OR1R2) and 10/238 (RBC5; Brr) were established as World Health Organisation (WHO) Reference Reagents for blood group genotyping in October 2011. They are intended to control test procedures for common alleles in Caucasian and black African populations

To order the Reference Reagents or to read the instructions for use, see the side panel.

Reference

Boyle J et al. (2013) International reference reagents to standardise blood group genotyping: evaluation of candidate preparations in an international collaborative study. Vox Sang. 104:144-52.

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