Establishing blood groups by genotyping is becoming increasingly used as it has a number of advantages over conventional blood group serology – when reliable and consistent serological reagents are unavailable to type minor antigens and variants, for blood-typing red cells with a positive direct antiglobulin test, and typing multiply transfused patients.
Genotyping can also be used to resolve reagent typing discrepancies, and predicting foetal Rh D phenotype and some other clinically important blood groups from cell-free foetal DNA in maternal blood.
Preparations 10/232 (RBC1; AR1R1), 10/234 (RBC12; ODΨ), 10/236 (RBC4; OR1R2) and 10/238 (RBC5; Brr) were established as World Health Organisation (WHO) Reference Reagents for blood group genotyping in October 2011. They are intended to control test procedures for common alleles in Caucasian and black African populations
To order the Reference Reagents or to read the instructions for use, see the side panel.
Boyle J et al. (2013) International reference reagents to standardise blood group genotyping: evaluation of candidate preparations in an international collaborative study. Vox Sang. 104:144-52.
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Dr Ross Hawkins - Principal ScientistDr Jennifer Boyle – Principal ScientistDr Pia Sanzone – Senior ScientistMr Malcolm Hawkins - Senior Scientist Dr Leandro Lo-Cascio - Senior ScientistMr Miltiades Stylianou – ScientistMr Noble Ossai - Scientist
10/232: International Reference Reagent: Genomic DNA for blood group genotyping RBC1(AR1R1)10/234: International Reference Reagent: Genomic DNA for blood group genotyping RBC12(ODΨ)10/236: International Reference Reagent: Genomic DNA for blood group genotyping RBC4(OR1R2)10/238: International Reference Reagent: Genomic DNA for blood group genotyping RBC5(Brr)11/214: International Reference Reagent: Blood Group Genotyping Reference PanelOther genomic reference materials