Proposed first WHO International Standards for EGFR variants

NIBSC is currently developing the proposed first WHO International Standards for Variants; four genomic DNAs each homozygous for one common variant. 

These materials are intended as both calibrants in the quantification of clinically-relevant EGFR variants p.L858R (c.2573T>G), p.T790M (c.2369C>T), p.E746_A750del (c.2235_2249del), p.E746_A750del (c.2236_2250del) and as reference materials to validate the performance of biomarker-based oncology diagnostic assays.

We are recruiting laboratories to assess and to support the establishment of these materials. To join our collaborative study, please email our Project Lead, Leandro.lo-cascio@nibsc.org