This product is a highly characterised single batch wild-type genomic DNA (gDNA) International Standard to be used as wild-type or diluent for PIK3CA c.1633G>A (E545K), TP53 p.R306*, NRAS p.G12C, PTEN p.K267fs*9, and MAP2K1/MEK1 p.D67N clinically-relevant variants. Additionally, the standard has been determined to be homozygous wild-type for PIK3CA, TP53, NRAS, PTEN, and MAP2K1/MEK1 gene copy numbers.
The International Standard was established by the WHO ECBS following an extensive collaborative study involving 35 laboratories across 22 countries and 5 continents and is suitable for any NGS (Next-Generation Sequencing) and dPCR (digital PCR) analysis.
NIBSC material code
Consensus variant percentage (%)
Consensus variant copy number per diploid human genome mass
Consensus total copy number per diploid human genome mass
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For more information on our International Standards for oncogene variant detection contact firstname.lastname@example.org.
Dr Ross Hawkins – Section HeadDr Ravneet BhullerMr Malcolm Hawkins Dr Leandro Lo CascioMr Noble OssaiDr Pia SanzoneMr Miltiades Stylianou
18/164: ATDB102 Reference Genome (WHO)Other genomic reference materials
Further information on ordering genomic reference materials from NIBSC.